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Dr. (Mrs) Usha Ghosh

Associate Professor, Head Chemical Engineering Department
Synthetic organic, organometallic, process, medicinal and polypeptide chemistry Ph.D. (Polypeptide Chemistry)

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Education:

·Ph.D.Degree awarded in 1992 from Bombay University. Working place: Bio-Organic Division, BARC, Mumbai, Maharashtra.

·M.Sc. First class from Garhwal University, Uttarakhand

·B.Sc.First class from Garhwal University, Uttarakhand

Academic Experience:

·Working since 2014 as Associate Professor (Chemistry) at Mukesh Patel school of Technology management and engineering, NMIMS deemed University.

·Post-doctoral research fellow at Department of Chemistry, University of Illinois at Urbana-Champaign, USA (1999-2001)

·Post-doctoral research fellow worked at Department of Chemistry, University of Cambridge, UK (1991-93)

·Worked as lecturer in R.J. College, Ghatkopar, Mumbai University (1985-87)

Certification or Professional Registrations:

·Coursera certificate for completing online course on "Introduction to Molecular Spectroscopy” from University of Manchester (2019)

·Drug discovery training at Residential School of Medicinal Chemistry, Drew University, New Jersey, USA (2012).

·Emerging leader program by Saya Leadership, organized by Piramal Enterprises Limited, Vikroli, Mumbai (2013).

·Six sigma yellow belt training organized at Piramal Enterprises Limited, Goregaon (2010).

·Laboratory safety training by Dr. James A Kaufman, Director LSI, Massachusetts, USA at IICT, Hyderabad (2006)

·Fire and safety training by Usha fire safety equipment Pvt. Ltd.(2008)

Honours and Awards:

·Research fellow award from Department of Science and Technology (DST) new Delhi worked at Bio-organic Division, Bhabha Atomic Research Center, Mumbai, India

·Post-doctoral research fellow worked with Prof. Ian Fleming, FRS in the Department of Chemistry, University of Cambridge, UK

·Post-doctoral research fellow worked and with Prof. John A. Katzenellenbogen in the Department of Chemistry, University of Illinois at Urbana-Champaign, USA

·Best research paper presentation awards at national and international forum

·Appreciation Letter for maintaining safety and good house- keeping at Piramal Research Centre Limited.

Service Activities

·Administrative roles in the school/University: Syllabus designing based on AICTE new model curriculum, Organizing seminar, workshop, industrial visit and guest lectures for faculties and student’s developments.

·Maintained Chemistry & chemical department related activities and assets.

·Organized educational visit for MBA Tech Chemical Students (2nd, 3rd,&4th year) and faculties chemical department on 23rd April, 2018 at Bhabha Atomic Research Centre, Trombay, Mumbai.

·Organized Industrial visit to Piramal Enterprise Limited for MBA-Tech chemical students 2017.

. Organized seminar on "Recent Advances in Food and Nutrition Technology” 2017, at MPSTME
. Organized
seminar on Enviro-Teck-1 &2” 2017 and 2018 at MPSTME

·

Positions Held:

·Head Chemistry & Chemical Engineering Department, MPSTME (2017-2018)

·Senior Group Leader (2006-2013) Piramal Enterprises Limited, 1, Nirlon complex, Off Western Express Highway, Goregaon (East), Mumbai.

·Group Leader (2004-2006) Nicholas Piramal Research Centre, 1, Nirlon complex, Off Western Express Highway, Goregaon (East), Mumbai.

·Senior Research Scientist (2001-2004), Quest Institute of Lifesciences (Formerly, Hoechst Marion Aventis Ltd.), Mulund, Mumbai.

·Assistant Manager (1995-1999), Nicholas Piramal India Ltd., (Formerly, Roche Products Ltd.) Vitamin & Fine Chemicals Division, Balkum, Thane.

·Executive-Organic Synthesis (1994-1995), Sun Pharmaceutical Advanced Research Centre, Akota Road, Baroda.

External Invitations and Guest Speaker:

·Co-ordinator and invited guest for the award distribution ceremony of Blast Carbo- FICCI India Chem 2018- Make in India, Swachh Bharat & Smart City 2018. Bombay Exhibition Center, Goregaon.

·Mentor for Action for collective transformation (ACT), Maharashtra (2017-18)

·One-day seminar and prestigious Prof. NR Kamath quiz competition-2018 at MPSTME in association with Indian Institute of Chemical Engineers (IIChE)

Publication in Last Five Years: (Total Publications research paper 19 and conference paper 15 till Date – 34, Only important publications are shown)

Publications:

1. With SS Pandit, MR Kulkarni, YB Pandit, NP Lad; Molecular diversity 22 (3), 545-560,2018. Synthesis and biological evaluation of imidazo [1, 2-] pyridazines as inhibitors of TNF- alpha production.

2. With Mahesh R. Kulkarni, Madhav S. Mane, Rajiv Sharma, Nitin P. Lad, Ankita Srivastava, Asha Kulkarni-Almeida, Prashant S. Kharkar, Vijay M. Khedkar, Shivaji S. Pandit; European Journal of Medicinal Chemistry, Volume 134, 7 July 2017, Pages 366-378. Discovery of tetrahydrocarbazoles as dual pERK and pRb inhibitors.

3. With Smriti Khanna, Chandrika B-Rao, Asha-Almeida, Rajiv Sharma; Biointerface Research in Applied Chemistry, Volume 6, Issue 4, 2016, 1422-1427 Discriminating between active and inactive compounds using binding energy calculations-a case study.

4.With K. Bajaj, S. Burudkar, P. Shah, A. Keche, P. Tannu, S. Khanna, A. Srivastava, N. J. Deshmukh, A. Dixit, Y. Ahire, A. Damre, K. V.S. Nemmani, A. Kulkarni-Almeida, C. B-Rao, R. Sharma, H. Sivaramakrishnan, Bioorganic & Medicinal Chemistry Letters, 2013,23, 834-838; Lead optimization of isocytosine-derived xanthine oxidase inhibitors.

5.With S. Khanna, S. Burudkar, K. Bajaj, P. Shah, A. Keche, A. Desai, A. Srivastava, A. Kulkarni-Almeida, N. J. Deshmukh, A. Dixit, M. K. Brahma, U. Bahirat, L. Doshi, K.r V.S. Nemmani, P. Tannu, A. Damre, C. B-Rao, R. Sharma, H. Sivaramakrishn, Bioorganic & Medicinal Chemistry Letters, 2012, 22, 7543-7546; Isocytosine-based inhibitors of xanthine oxidase: Design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia

6.With C. B-Rao, A. Kulkarni-Almeida, K. V. Katkar, S. Khanna, A. Keche, P. Shah, A. Srivastava, V. Korde, K. V.S. Nemmani, N. J. Deshmukh, A. Dixit, M. K. Brahma, U. Bahirat, L. Doshi, R. Sharma, H. Sivaramakrishnan, Bioorganic & Medicinal Chemistry, 2012, 20, 2930-2939; Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits.

7.With R. Bhattacharyya, A. Keche, Tetrahedron,2010, 66, 2148-2155; Mild and efficient syntheses of diverse isoindolinones from ortho-phthaldehydic acid methylthiomethyl ester.

 

Patents

1. Method of use of Epiregulin protein and nucleic acid encoding the same in inflammatory conditions;PCT/IB2007/054689.

2. Imidazopyridine compounds and uses thereof Patent for TNF-alpha blockers filed;PCT/IB2012/056580

3. Tricyclic Guanidine Derivatives as Sodium-Proton Exchange Inhibitor. PCT/IB2005/053653 dated: 08 Nov. 2005.

4. Fused Tricyclic Compounds as Inhibitors of Tumor Necrosis Factor-Alpha. PCT/IB2005/053654 dated: 08 Nov. 2005.

Recent conferences:

1)Presented paper at conference on Desalination and Water Purification for Defense and Civil Applications organized by DRDO, Jodhpur, March, 2017

2)Presented paper at conference on Global challenges in Drug discovery, development and regulatory affairs at Nirma University, Ahmedabad, Gujrat, NIPICON 2016.

3)Presented paper on Synthesis of Novel Isocytosine Based Xanthine Oxidase inhibitors; presented at 19th ISCB International Conference (ISCBC-2013), 2nd -5th March, 2013 at Udaipur, Rajasthan.

4)Presented paper on Synthesis and evaluation of 6-Aryl-imidazo[1,2-b]pyridazine -3- sulphonamides for tumor necrosis factor-alpha (TNF-a) production inhibitory activity,presented at 19th ISCB International Conference (ISCBC-2013), 2nd -5th March, 2013 at Udaipur, Rajasthan.

5)Presented paper on the discovery of 3-((5-phenyl-1,3,4-oxadiazol-2-yl)thio)benzo[b]thiophene 1,1-dioxide based inhibitors of tumor necrosis factor-alpha (TNF-a) production, presented at 19th ISCB International Conference (ISCBC-2013), 2nd -5th March, 2013 at Rajkot, Gujrat.

6)Presented paper on Mild and Efficient Syntheses of Diverse Isoindolinones from Ortho-phthaldehydic Acid Methylthiomethyl Ester, presented at International Conference on Current Trends in Chemistry and Biochemistry(ICCTCB-2009) at Banglore University.

7)Presented paper on Substituted 3-(Phenylthiomethyl)-4h-Chromen-4-Ones as Potent Inhibitors of Inflammatory Cytokines, presented at 2010 Medicinal Chemistry Gordon Conference, New London, USA.

8)Presented paper on Quantitative bioanalysis of a novel drug (P979) and its metabolite (P978) using a stable isotopically labeled internal standard by LC-MS-MS ; presented at international conference PITTCON – 2007 February 25 to March 2, 2007, Chicago, Illinois, USA

 

 


           
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